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landmark study Reveals

PreTRM® Test and targeted interventions usher in a new era of personalized prenatal care 

The recent 19-center randomized controlled trial PRIME (Neonatal impact of maternal biomarker screening for risk of preterm birth with targeted interventions [PRIME]: A multicenter, randomized, controlled trial), supports a new evidence-based approach to early identification and care for those at higher risk of spontaneous preterm birth. In this study, the PreTRM Test was used to screen a representative population of clinically low-risk patients with singleton pregnancies.  

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Significantly improve
neonatal outcomes

PRIME, published in peer-reviewed journal, PREGNANCY,
demonstrated these key findings: 

Fewer health complications for newborns

20% reduction in neonatal morbidity and mortality.

Increase in Gestational Age

56% and 32% fewer babies were born before 32 and 35 weeks, respectively.

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DECREASE IN NICU ADMISSIONS

20% fewer babies admitted to the NICU.

Only 4.2 women needed to be screened with PreTRM® to prevent 1 day in the NICU.1

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IMPLEMENT IN PRACTICE

PRIME delivers clear direction on managing higher-risk pregnancies

Patients were screened with the PreTRM® Test, a blood-based biomarker test designed to identify high-risk singleton pregnancies lacking evident clinical risk factors. If their results indicated they were not higher risk, they received standard of care treatment. If their results indicated they were at higher risk, they received targeted, easily accessible interventions. 

  1. Daily low-dose aspirin (81 Mg)
  2. Care management, consisting of weekly nurse calls
  3. Daily intravaginal progesterone (200 Mg)

The PRIME Study concluded that the PreTRM Test, paired with safe and affordable interventions, significantly improves outcomes for mothers and babies.

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PERSISTENTLY HIGH RATES OF PRETERM BIRTH REQUIRE EDUCATION 

Most women don’t know about preterm birth

Preterm birth affects 1 in 10 pregnancies and can have serious – even fatal – consequences.2

Real Experiences,
Real Impact.

  • Medical Provider
  • Patient

The PreTRM Test can be critical in delivering preemptive, informed care to pregnant women. More than half of women who deliver prematurely have no evident risk factors. Having a clear understanding of a woman’s risk allows us to create a simple, low-cost yet effective intervention strategy that can improve outcomes for the patients I serve.

Brian Iriye, MD Maternal Fetal Medicine Specialist

As a result of the weekly check-ins & overall care management, I was well-informed and empowered to advocate for myself and my baby.

Bonnie Actual PreTRM Patient Story
LANDMARK STUDY
PreTRM® Test Significantly Reduces Newborn Morbidity & Mortality
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References

  1. Iriye BK, O’Brien JM, Ennen CS, et al. Neonatal impact of maternal biomarker screening for risk of preterm birth with targeted interventions (PRIME): A multicenter, randomized, controlled trial. Pregnancy 2026;2(1):e70202. DOI: https://doi.org/10.1002/pmf2.70202.
  2. Hamilton BE, et al. Births: Provisional data for 2020. Vital Statistics Rapid Release; no 12. Hyattsville, MD: National Center for Health Statistics. May 2021